Cardiac Neural Crest and Congenital Heart Defects
نویسندگان
چکیده
منابع مشابه
Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects.
OBJECTIVE Congenital heart defects represent the most common human birth defects. Even though the genetic cause of these syndromes has been linked to candidate genes, the underlying molecular mechanisms are still largely unknown. Disturbance of neural crest cell (NCC) migration into the derivatives of the pharyngeal arches and pouches can account for many of the developmental defects. The goal ...
متن کاملHemodynamic changes in chick embryos precede heart defects after cardiac neural crest ablation.
Neural crest cells are known to contribute to the normal architecture of the heart and aortic arch arteries. Ablation of neural crest cells over somites 1 to 3 in the chick embryo prevents conotruncal septation and results in persistent truncus arteriosus. To determine whether a deficiency of cardiac neural crest cells produces hemodynamic changes prior to the development of identifiable struct...
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Mutations in subunits or regulators of cohesin cause a spectrum of disorders in humans known as the 'cohesinopathies'. Cohesinopathies, including the best known example Cornelia de Lange syndrome (CdLS), are characterized by broad spectrum, multifactorial developmental anomalies. Heart defects occur at high frequency and can reach up to 30% in CdLS. The mechanisms by which heart defects occur a...
متن کاملRole of neural crest in congenital heart disease.
In the preface for his monograph on neural crest in 1950, Horstadius' wrote, "Most text-books of embryology or anatomy make only passing mention of the neural crest as the source of origin of one or two structures in the vertebrate body. Few books devote even as much as a page to this interesting structure." Although the passage of 40 years has seen a revolution in our understanding of the neur...
متن کاملA novel role for cardiac neural crest in heart development.
It is well known that cardiac neural crest participates in development of the cardiac outflow septation and patterning of the great arteries. Less well known is that ablation of the cardiac neural crest leads to a primary myocardial dysfunction. Recent data suggests that the myocardial dysfunction occurs because of the absence of an interaction of neural crest and pharyngeal endoderm to alter s...
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ژورنال
عنوان ژورنال: Pediatric Cardiology and Cardiac Surgery
سال: 2012
ISSN: 0911-1794
DOI: 10.9794/jspccs.28.110